The Overall Center Organization and Management Plan includes the Administrative Core, three research cores, and four research projects, led by promising junior investigators. The Administrative Core oversese establishment and operation of the center, the three research cores, and a faculty development plan. The integrated and interactive faculty development plan includes a formal mentoring program that guides our four junior investigators to independence. The CMDR research cores include a Genetic Models Core that uses cutting-edge approaches to genetically manipulate cells and mice, a Bone Histology and Imaging Core that analyzes mouse and human hard tissues, and a Bioinformatics Core that analyzes the large datasets generated by the molecular analyses of cells from mouse and human samples.