Genetic Models Core

Director: Charles O’Brien, Ph.D.

The Genetic Models Core provides state-of-the-art services to create novel genetically modified mice and cell lines. This core was created by expanding an existing transgenic mouse facility at UAMS, which has a strong record of producing transgenic mice. An important new addition is the use of the CRISPR-Cas system to provide gene-editing services in both mice and cell lines. This expansion of services establishes a Genetic Models Core that, in addition to meeting the needs of the COBRE Project Leaders, provides new cutting-edge services to the research communities at UAMS, ACRI, CAVHS, and across Arkansas.  The Genetic Models Core also provides maintenance services, including sperm cryopreservation, in vitro fertilization, and strain rederivation, all of which support the long-term needs of Project Leaders and other Center members.

Bone Histology and Imaging Core

Director: Roy Morello, Ph.D.

This core provides a wide range of services to analyze both murine and human skeletal tissue, including state-of-the-art imaging (Dual energy x-ray absorptiometry, microCT, and IVIS), tissue sectioning (paraffin, methyl methacrylate, and frozen), and biomechanical testing (vertebral compression and three-point bending).

Bioinformatics Core

Director: Intawat Nookaew, Ph.D.

This core provides cutting-edge analyses of large datasets.  The Bioinformatics Core has assembled a team of bioinformatics specialists with access to a state-of-the-art computational facility.